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In a separate study, administration of the prostaglandin E2 receptor 2 antagonist TG11-77.HCl to female 5xFAD mice significantly reduced the mRNA expression of proinflammatory cytokines (IL-1β, tumor necrosis factor, IL-6, C-C motif ligand 2, and prostaglandin E2 receptor 2) and glial activation markers (Iba1, glial fibrillary acidic protein, CD11b, and S100B) that were upregulated following lipopolysaccharide stimulation (Banik et al., 2021)