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47 The total urate clearance of propofol is significantly more than other situations that result in increased urate clearance, such as artificially induced hyperuricemia (14.4 ml/min)47, 48 or hypoxanthine-guanine phosphoribosyltransferase deficiency: 11.7 ml/min (range 4.2–20.8 ml/min)

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Methods Materials GSH, GSSG, 2-mercaptoethanol, ophthalmic acid, S -methylglutathione and yeast glutathione reductase (GR) were obtained from Sigma-Aldrich, HEDS was from Alfa Aesar, GSSCys from Toronto Research Chemicals and NADPH was from Gerbu