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As shown in Figure 93, EPT has been proposed a 1e − /2H + MS-EPT step for the initial S 0 → S 1 stage in the Kok cycle with electron transfer from the Mn(4) site in the Mn 4 Ca cluster to Y Z ·

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This may be along with general COX 1 and COX 2 specificity (24), with the pyloric sphincter less sensitive to COX 2 and the lower esophageal sphincter more sensitive, but ultimately both affected by inhibition of both COX 1 and COX 2