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This is not surprising taking into account the highly flexible nature of IDPs/IDRs, which are best described as a “protein clouds”, and the fact that the utilized ensemble low-resolution techniques measure signals representing an average of all the states present in the conformational ensemble, and thereby conceal information about individual structures and their specific features

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In this article, we’ll take a good look at the science on IT Band Syndrome and hopefully give you some confidence to get around it