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Investigational use requires appropriate institutional oversight and cannot substitute for FDA-approved metabolic therapies with established clinical efficacy

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However, this review also noted that patients in the Armour Thyroid group were more likely to report adverse effects such as palpitations as compared to those on levothyroxine sodium alone.4 Another randomized, double-blind crossover study had patients take either DTE or levothyroxine sodium for 16 weeks, then switch to the other group for the same duration