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Melillo agrees: "We can't definitively say that 0.5% is the minimum effective amount or that 1% will produce better results." The percentage on the label, it turns out, is almost beside the point

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They measured subjective sleep quality more than objective sleep quality They subjectively estimated tiredness Sleep structure was not fully characterized by polysomnography in all studies Data analysis suggested some observed changes were due to issues with the placebo group What is promising about these findings is that statistically significant effects were found in such small sample sizes

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