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NPs smaller than 3 µm can be internalized into non-phagocytic cells via non-specific endocytosis (29), while the maximum particle size available for endocytosis increases to 5 µm (19), facilitated by the abundant M cells in the intestinal Peyer's patches (21) and aided by the intestinal mucosal membranes (30,31)

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For acute detoxification (heavy metal chelation, acetaminophen overdose support), IM's faster absorption is preferable

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