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In conclusion, the murine model of an iron-overloaded liver used in the present study demonstrated that taurine supplementation has beneficial effects on liver function and apoptosis, with marked reductions in oxidative stress induced by iron overload

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Nuclear exclusion of p53 reportedly leads to translocation of p53 to mitochondria and transcription-independent induction of apoptosis [28], which may explain the therapeutic effect of FOXO4-DRI