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Leu, Ile, and Val) in macrophages can not only replenish TCA cycle-related intermediates through BCAT/BCKDH-mediated catabolism, but also influence inflammation-related transcriptional programs through transport and nutrient-sensing pathways, such as mechanistic target of mTORC1 (62)

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Immunomodulatory actions of sitagliptin have also been described in human subjects with type 2 diabetes