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iNOS inhibitors such as aminoguanidine and 1400W decrease neuroinflammation, oxidative damage, and neuronal degeneration in animal models of stroke, traumatic brain injury, and neurodegeneration ( By decreasing inflammation, NO●/ONOO – production, and antioxidant defenses, combinatorial approaches that decrease iNOS and increase Nrf2 or SIRT1 activity can enhance neuro-protection ( Ferroptosis and neuroinflammation of the central nervous system depend on the iNOS/NO● axis ( 4.6 Nutritional modulation of ferroptosis: implications for neuroprotection and healthy aging Ferroptosis is a very sensitively regulated process with nutritional and metabolic signals, where its performance is directly regulated by iron supply, lipid peroxidation processes, and cellular antioxidant levels

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