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The analysis, which was done by the authors, identified a genome-wide non-synonymous SNP in the cubilin gene (CUBN, rs1801222/p.S253F), which was significantly associated with metformin-induced vitamin B12 deficiency

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Du Preez A, Onorato D, Eiben I, Musaelyan K, Egeland M, Zunszain PA, et al

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