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Olaparib treatment also replenished NAD + levels, enhanced mitochondrial function, and promoted fatty acid oxidation, thereby reversing non-alcoholic fatty liver disease (NAFLD) in mice fed a high-fat, high-sucrose diet 164 (Fig

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Recent breakthrough findings have identified GTPSCS as lactyl-CoA synthase in glioma cell nuclei, which promotes glioma progression through p300-mediated histone lactylation (Liu et al., 2025)