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Then, the sugar‐phosphate backbone is cleaved by AP endonuclease 1 (APE1) activity, and the resulting gap is filled with a single‐nucleotide match (short‐patch BER) or a few long matches (long‐patch BER) [87]

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Acetaminophen is metabolized to nontoxic glucuronide and sulfate conjugates, and to a highly reactive metabolite N -acetyl- p -benzoquinoneimine (NAPQI) via CYP isoforms