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This goes with its ample range of beneficial effects, obtained within the same dose range [1,2,3,4,5,6,7,8,9,10,11,15,27,28,29,30,33,109,124,125], as the most valuable proof of the neurotransmitter requires that the application of the chemical directly to the target cells should produce the same response observed when the chemical is naturally released from the neurons [12,13,14]

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“Q14 Analytical Procedure Development.” FDA Guidance Document