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In parallel, metal-based agents derived from ruthenium, iron, and platinum continue to advance through experimental clinical evaluation for cancer, and ferroquine (5) has reached clinical testing for malaria (Figure 4) (Nriagu and Skaar, 2015)
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326,327 In patients with CAPS, inflammasome hyperactivation in the skin and joints gives rise to urticarial-like but nonpruritic rashes, arthralgia or frank arthritis, and episodes triggered by cold exposure