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The role of glutathione S-transferases in human disease pathogenesis and their current inhibitors - PMC

These results demonstrate that microRNA-141 targets Keap1 to provoke Nrf2 activation and attenuates UV-induced oxidative stress in RGCs [75]

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That uncertainty is precisely why it remains an interesting research tool rather than a settled one, and it is stated plainly here rather than papered over with confident mechanism claims