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Typically, whole-genome duplication (WGD), segmental duplication, and tandem duplication events are regarded to be the key driving factor for producing new genes and gene family expansion (Rensing, 2014)

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[93] reported that IL-6 and IL-17a concentrations increase with the progression of AR and suggested that clinical testing for IL-6 and IL-17a could improve the diagnosis of early AR and prevent disease progression