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may cause iron-deficiency anemia Nausea and vomiting — particularly with stricturing disease/obstruction Urgency and tenesmus — with rectal/colonic involvement Weight loss and malnutrition — due to malabsorption, food avoidance, elevated metabolic demand Fever — with active inflammation, abscess, or fistula Perianal disease — fissures, fistulae, skin tags, abscesses Extraintestinal Manifestations Arthropathy — peripheral or axial (enteropathic arthritis, M07.6x) Dermatologic: Erythema nodosum (L52), pyoderma gangrenosum, psoriasis (L40.5) Ocular: Uveitis/iritis (H20.01), episcleritis, scleritis Hepatobiliary: Primary sclerosing cholangitis (K73.2), fatty liver, cholelithiasis Metabolic: Osteopenia/osteoporosis (from steroid use and malabsorption), nephrolithiasis Hematologic: Anemia (iron deficiency, B12/folate deficiency, anemia of chronic disease) When a patient with Crohn’s disease is admitted with significant weight loss, malnutrition, or protein-calorie deficiency , query the provider to specify the degree of malnutrition (mild, moderate, severe protein-calorie malnutrition)
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MTHFR C677T and A1298C polymorphisms may contribute to the risk of Parkinson’s disease: A meta-analysis of 19 studies
