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The first is the result of a mechanical blockade occurring in the biliary duct system caused by the presence of a gallstone, or a consequence of a pressure on bile ducts caused by tumor mass, bile duct tumors themselves, pancreatic tumors, pancreatitis, cysts, or primary sclerosing cholangitis

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Other strategies include dopamine agonists that bind to the dopamine receptors in the pituitary gland and block the secretion of prolactin and GH