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Treatment Parameter Insights From This Meta-Analysis Important: Microneedling at clinical depths (1.0+ mm) should be performed by or under the guidance of a healthcare professional

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In SLE, these mechanisms restore immune balance by curbing pathogenic Th2 overactivation (e.g., IL-5/IL-13) while enhancing regulatory IgA synthesis and Treg-mediated suppression of autoreactive B cells (51, 129)